Endocrine Abstracts

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules. Material and methods Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by four endocrinologists and DSS, before and after the use of AI was evaluated.Results: A...

Objective: Evaluate the utility of analytical determination of parathyroid hormone assay in fine-needle aspirate as a diagnostic test for parathyroid adenoma in patients with primary hyperparathyroidism.Material and Methods: retrospective observational study of 58 patients diagnosed with primary hyperparathyroidism in our hospital who underwent ultrasound-guided FNA of lesions compatible with parathyroid adenoma with determination of PTH in fine-needle a...

Background: Thionamides are a class of drugs used to control thyrotoxicosis. A wide range of systemic adverse effects have been described, including agranulocytosis, rash, fever, arthralgia, hepatitis and even drug-induced lupus. Besides, there are some uncommon events related to their use, such as pleural effusion (only eight cases have been previously reported). We report a case of methimazole-induced eosinophilic pleural effusion.Case: Our patient is ...

Introduction: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe multiorgan drug reaction, often associated with the development of autoimmune diseases. Pathogenically it has been related to the reactivation or the primary infection of different herpes virus.Clinical case: A 33-year-old woman with a history of residual epilepsy, after resection of a cerebellar pleomorphic xantoastrocytoma, started treatment with Levetirace...

Introduction and objectives: Metformin (MTF) is the most used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). However, intolerance to drug is frequent and limits its use. There are controversies about the cause of this problem, the gut microbiota has been proposed to be responsible. The gradual introduction of MTF could exercise an adaptation of gut microbiota that would facilitate tolerance to MTF. In this study we evaluate the metabolic changes and gut mic...

Introduction: Patients with primary adrenal insufficiency (PAI) require lifelong corticoids replacement and they are at risk of therapy-related osteoporosis and cardiovascular complications.Objectives: Determine the prevalence of cardiovascular risk factors, osteoporosis, and other toxicities related with corticoids treatment.Material and methods: Retrospective, descriptive study in patients with PAI follow up in our service during...

Introduction: The multidisciplinary approach of the patients with GEP-NETs is very important, having a fundamental role the participation of the endocrinologist.Methods: Description of cases of GEP-NETs followed in the Service of Endocrinology of the SCCH from 1990 to 2016.Results: 95 patients were included, 53.7% were males, age 61.2 years (IR: 50.5–73.5). The diagnosis was incidental in 53.8%. 27.6% presented clinical secret...

Introduction: Neuroendocrine tumors (NETs) constitute a very heterogeneous group of rare neoplasms, although their incidence has increased in recent years. We describe its evolution and survival.Methods: Retrospective study. All patients with histopathological diagnosis of GEP-NETs performed at the HCSC between 2000 and 2016 were selected, data from the medical history were included. Statistical analysis were done with SPSS.Results...

Objectives: To evaluate the different insulin regimens and types of insulin used in our population of type 1 diabetes (DM1) patients in the last revision in our clinic.Method: A descriptive study was carried out in our population of 535 DM1 patients. They had their initial diagnosis between 1967 and 2014.Results: In our population, 47.3% were women and 52.3% were men. The mean age of our patients was 33.8 years (S.D....

Introduction: Metformin is used as a first line treatment in type 2 diabetes. Several studies suggest that patients with type 2 diabetes treated with metformin may have reduced cancer risk. Recently it has been shown that Metformin acts directly on mitochondria to alter cellular bioenergetics and reduce tumorigenesis. We have shown that anti-proliferative effect of Mitotane is related with changes of expression of the genes involved in mitochondrial metabolism in human adrenoc...